Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

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Détails bibliographiques
Auteur principal: Petrick, Joy Kristin
Autres auteurs: Klebe, Gerhard (Prof. Dr.) (Directeur de thèse)
Format: Dissertation
Langue:anglais
Publié: Philipps-Universität Marburg 2019
Sujets:
Pharmakologie, Therapeutik
mevalonate
farnesyl pyrophosphate
kissing bug
Isoprenoid
FPPS
Fragment-basierte Wirkstoffforschung
FDPS
Chagas disease
Chagas
fragment based drug discovery
Protein-Kristallograph
protein cry
isoprenoid
Vernachlässigte Krankheit
Farnesylpyroposphate-Synthase
neglected disease
Pharmacology & therapeutics, prescription drugs
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