Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

Trypanosoma brucei (T. brucei) is the causative agent of the Human African Trypanosomiasis (HAT), which is a neglected disease with an endemic occurrence in 36 sub-Saharan African countries. The current standard of care suffers from low efficacy and severe side effects. Therefore, new drugs with bet...

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Bibliographic Details
Main Author: Münzker Lena
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
Pharmakologie, Therapeutik
Farnesylpyrophosphat-Synthase
Trypanosoma brucei
Fragment-basierte Wirkstoffentwicklung
farnesyl pyrophosphate synthase
Fragment-based drug discovery
Pharmacology & therapeutics, prescription drugs
Online Access:PDF Full Text
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