Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

Hassaan, Engi

Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

There are several biophysical methods developed to rapidly identify weakly binding fragments to a target protein. X-ray crystallography provides structural information that is crucial for fragment optimization, however there are several criteria that must be met for a successful fragment screening...

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Hlavní autor:	Hassaan, Engi
Další autoři:	Klebe, Gerhard (Prof. Dr.) (Vedoucí práce)
Médium:	Dissertation
Jazyk:	angličtina
Vydáno:	Philipps-Universität Marburg 2019
Témata:	drug discovery peroxin 14 NMR x-ray crystallography comparative analysis fragment screening SPR endothiapepsin tRNA guanine transglycosylase Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
On-line přístup:	Plný text ve formátu PDF
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Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

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