Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

There are several biophysical methods developed to rapidly identify weakly binding fragments to a target protein. X-ray crystallography provides structural information that is crucial for fragment optimization, however there are several criteria that must be met for a successful fragment screening...

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Autor principal: Hassaan, Engi
Altres autors: Klebe, Gerhard (Prof. Dr.) (Assessor de tesis)
Format: Dissertation
Idioma:anglès
Publicat: Philipps-Universität Marburg 2019
Matèries:
drug discovery
peroxin 14
NMR
x-ray crystallography
comparative analysis
fragment screening
SPR
endothiapepsin
tRNA guanine transglycosylase
Pharmakologie, Therapeutik
Pharmacology & therapeutics, prescription drugs
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