Totalsynthesen von (+)-Elevenol, (+)-Przewalskin und (+)-Nivetetracyclat A
In der vorliegenden Arbeit wurden die beiden Naturstoffe (+)-Elevenol und (+)-Przewalskin erstmals erfolgreich und enantiomerenrein synthetisiert. Dabei konnte (+)-Elevenol in einer 14-stufigen Synthese in einer Gesamtausbeute von 7% dargestellt werden. Ausgehend von (+)-Elevenol konnte eine wei...
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| Format: | Doctoral Thesis |
| Language: | German |
| Published: |
Philipps-Universität Marburg
2019
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| Online Access: | PDF Full Text |
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Table of Contents:
This work describes the first successful and entantioselective synthesis of (+)-Elevenol and
(+)-Przewalskin. Elevenol was synthesized in 14 steps with an overall yield
of 7%. Coming from (+)-Elevenol a defunctionalization lead to the construction of another
dinorditerpene (+)-Przewalskin in 17 steps and an overall yield of 3%.
The first successful enantioselective total synthesis of Nivetetracylate A is described in
this work. Nivetetracyclate A was synthesized in 17 linear steps with an overall yield of
0.9%.