Totalsynthesen von (+)-Elevenol, (+)-Przewalskin und (+)-Nivetetracyclat A

In der vorliegenden Arbeit wurden die beiden Naturstoffe (+)-Elevenol und (+)-Przewalskin erstmals erfolgreich und enantiomerenrein synthetisiert. Dabei konnte (+)-Elevenol in einer 14-stufigen Synthese in einer Gesamtausbeute von 7% dargestellt werden. Ausgehend von (+)-Elevenol konnte eine wei...

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Bibliographic Details
Main Author: Blitz, Michel
Contributors: Koert, Ulrich (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2019
Online Access:PDF Full Text
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Table of Contents: This work describes the first successful and entantioselective synthesis of (+)-Elevenol and (+)-Przewalskin. Elevenol was synthesized in 14 steps with an overall yield of 7%. Coming from (+)-Elevenol a defunctionalization lead to the construction of another dinorditerpene (+)-Przewalskin in 17 steps and an overall yield of 3%. The first successful enantioselective total synthesis of Nivetetracylate A is described in this work. Nivetetracyclate A was synthesized in 17 linear steps with an overall yield of 0.9%.