Directed Evolution of an Fe(II)-Dependent Halogenase for Asymmetric C(sp3)-H Chlorination

Directed Evolution of an Fe(II)-Dependent Halogenase for Asymmetric C(sp3)-H Chlorination

Within this thesis, the chlorinase Wi-WelO15 from Westiella intricata UH strain HT-29-1 was explored for its evolvability towards non-natural substrates and its biocatalytic applicability. Organohalogens play an important role as pharmaceuticals and agricultural chemicals or synthetic intermediat...

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Bibliographic Details
Main Author: Düwel, Sabine
Contributors: Höbenreich, Sabrina (Dr. rer. nat.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2018
Subjects:
halogenase
gerichtete Evolution
Chemie
Biokatalyse
directed evolution
biocatalysis
Halogenase
Chemistry & allied sciences
Online Access:PDF Full Text
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