Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Over the last 20 years, the consideration of biophysical parameters such as kinetics and thermodynamics has been used to guide modern drug design. In contrast to the classical approach that mainly relies on affinity optimization, biophysical parameters allow a further discrimination of potential dru...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijä: Wienen-Schmidt, Barbara
Muut tekijät: Klebe, Gerhard (Prof.) (BetreuerIn (Doktorarbeit))
Aineistotyyppi: Dissertation
Kieli:englanti
Julkaistu: Philipps-Universität Marburg 2017
Aiheet:
Protein Kinase A (PKA)
Selektivität
Fasudil
Inhibition
Pharmakologie, Therapeutik
X-ray Crystallography
Entropie
NMR
Thermodynamik
Freiheitsgrad
isothermal titration calorimetry (ITC)
Röntgenstrukturanalyse
Inhibitor
Dynamik
15N-
Kinases
Enthalpie
Kinase
Dynamics
Thermodynamics
isotherme Titrationskalorimetrie (ITC)
15
Pharmacology & therapeutics, prescription drugs
Linkit:PDF-kokoteksti
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