Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Over the last 20 years, the consideration of biophysical parameters such as kinetics and thermodynamics has been used to guide modern drug design. In contrast to the classical approach that mainly relies on affinity optimization, biophysical parameters allow a further discrimination of potential dru...

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Gorde:
Xehetasun bibliografikoak
Egile nagusia: Wienen-Schmidt, Barbara
Beste egile batzuk: Klebe, Gerhard (Prof.) (Tesi aholkularia)
Formatua: Dissertation
Hizkuntza:ingelesa
Argitaratua: Philipps-Universität Marburg 2017
Gaiak:
Protein Kinase A (PKA)
Selektivität
Fasudil
Inhibition
Pharmakologie, Therapeutik
X-ray Crystallography
Entropie
NMR
Thermodynamik
Freiheitsgrad
isothermal titration calorimetry (ITC)
Röntgenstrukturanalyse
Inhibitor
Dynamik
15N-
Kinases
Enthalpie
Kinase
Dynamics
Thermodynamics
isotherme Titrationskalorimetrie (ITC)
15
Pharmacology & therapeutics, prescription drugs
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