Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Wienen-Schmidt, Barbara

Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Over the last 20 years, the consideration of biophysical parameters such as kinetics and thermodynamics has been used to guide modern drug design. In contrast to the classical approach that mainly relies on affinity optimization, biophysical parameters allow a further discrimination of potential dru...

Celý popis

Uloženo v:

Podrobná bibliografie
Hlavní autor:	Wienen-Schmidt, Barbara
Další autoři:	Klebe, Gerhard (Prof.) (Vedoucí práce)
Médium:	Dissertation
Jazyk:	angličtina
Vydáno:	Philipps-Universität Marburg 2017
Témata:	Protein Kinase A (PKA) Selektivität Fasudil Inhibition Pharmakologie, Therapeutik X-ray Crystallography Entropie NMR Thermodynamik Freiheitsgrad isothermal titration calorimetry (ITC) Röntgenstrukturanalyse Inhibitor Dynamik 15N- Kinases Enthalpie Kinase Dynamics Thermodynamics isotherme Titrationskalorimetrie (ITC) 15 Pharmacology & therapeutics, prescription drugs
On-line přístup:	Plný text ve formátu PDF
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

No citations were found for this record.

Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Podobné jednotky