Synthese und Charakterisierung substratanaloger Inhibitoren der Serinproteasen Matriptase und Kallikrein 7

Die Serinproteasen Matriptase und Kallikrein 7 sind in einer Vielzahl physiologischer Prozesse involviert. Eine gestörte Aktivität dieser Proteasen ist für eine Reihe von Erkrankungen verantwortlich. Daher ist es von therapeutischem Interesse, die Aktivität der Proteasen regulieren zu können....

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Bibliographic Details
Main Author: Maiwald, Alexander
Contributors: Steinmetzer, Torsten (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2017
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Table of Contents: The serine proteases matriptase and kallikrein 7 are involved in a variety of physiological processes. A disturbed activity of these proteases is responsible for a number of diseases. Therefore, it is of therapeutic interest to be able to regulate the activity of these proteases. For this purpose, a series of substrate-analogue inhibitors for matriptase and kallikrein 7 have been developed and investigated for their inhibitory potency. Potent and selective inhibitors were developed for both proteases.