Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study

Water molecules participate besides protein and ligand as an additional binding partner in every in vivo protein–ligand binding process. The displacement of water molecules from apolar surfaces of solutes is considered the driving force of the hydrophobic effect. It is generally assumed that the...

詳細記述

保存先:
書誌詳細
第一著者: Krimmer, Stefan Günter
その他の著者: Klebe, Gerhard (Prof. Dr.) (論文の指導者)
フォーマット: Dissertation
言語:英語
出版事項: Philipps-Universität Marburg 2017
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