Structure-Based Design of a Blood Coagulation Factor XIII Blocker

FXIII belongs to the family of transglutaminases, mainly catalyzing the cross-linking of proteins by formation of an isopetide bond between a glutamine and a lysine side chain. FXIII represents the last enzyme of the blood coagulation cascade providing final stability to the blood clot by cross-link...

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Bibliographic Details
Main Author: Stieler, Martin
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2017
Online Access:PDF Full Text
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