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From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin
The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...
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| 格式: | Dissertation |
| 语言: | 英语 |
| 出版: |
Philipps-Universität Marburg
2016
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| 主题: | |
| 在线阅读: | PDF-Volltext |
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PDF-Volltext| 索引号: |
urn:nbn:de:hebis:04-z2017-00684 |
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| Publikationsdatum: |
2017-02-07 |
| Datum der Annahme: |
2017-01-25 |
| Downloads: |
36 (2024), 104 (2023), 158 (2022), 143 (2021), 116 (2020), 178 (2019), 139 (2018) |
| Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
| 访问URL: |
https://archiv.ub.uni-marburg.de/diss/z2017/0068 https://doi.org/10.17192/z2017.0068 |