From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin

The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...

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Glavni avtor: Radeva, Nedyalka
Drugi avtorji: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2016
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Signatura: urn:nbn:de:hebis:04-z2017-00684
Publikationsdatum: 2017-02-07
Datum der Annahme: 2017-01-25
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2017/0068
https://doi.org/10.17192/z2017.0068