From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin
The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...
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Andere auteurs: | |
Formaat: | Dissertation |
Taal: | Engels |
Gepubliceerd in: |
Philipps-Universität Marburg
2016
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Onderwerpen: | |
Online toegang: | PDF Full text |
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Internet
PDF Full textPlaatsingsnummer: |
urn:nbn:de:hebis:04-z2017-00684 |
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Publicatiedatum: |
2017-02-07 |
Datum der Annahme: |
2017-01-25 |
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Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL naar item: |
https://archiv.ub.uni-marburg.de/diss/z2017/0068 https://doi.org/10.17192/z2017.0068 |