From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin

The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...

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Bibliografski detalji
Glavni autor: Radeva, Nedyalka
Daljnji autori: Klebe, Gerhard (Prof. Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:engleski
Izdano: Philipps-Universität Marburg 2016
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Signatura: urn:nbn:de:hebis:04-z2017-00684
Datum izdanja: 2017-02-07
Datum der Annahme: 2017-01-25
Downloads: 36 (2024), 104 (2023), 158 (2022), 143 (2021), 116 (2020), 178 (2019), 139 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL pristupa: https://archiv.ub.uni-marburg.de/diss/z2017/0068
https://doi.org/10.17192/z2017.0068