Vergleich von Schlaf EEG und kognitiver Leistungsfähigkeit bei Patienten mit idiopathischem Parkinsonsyndrom, Multisystematrophie und REM-Schlaf Verhaltensstörung

Summary The present study aims to compare sleep through polysomnography as well as the cognitive output profile with an comprehensive and strictly controlled neuro-psychological clarification with three certain groups of patients. In contrast to most previous studies on this subject we tried to examine patients of the three groups IPS, MSA and RBD in a rather early stage, i.e. shortly after giving of the diagnosis. Besides we investigated whether there is a correlation between the parameters of sleep-EEGs and the specified collection of cognitive output in these groups of patients. Considering the given limitations like small size of patient groups and the fact that we had to deal with a cross-section study and not a longitudinal study, the present work provides new aspects of the occurrence of disorders in cognitive output and sleep within these patient groups. Table of Contents: I. Introduction (p.5) II. Theoretic background(p.10) 1. PARKINSIN´s DISEASE, MULTISYSTEMATROPHIE and REM SLEEP BEHAVIOR DISORDER (p.10) 1.1 Classification(p.10) 1.2 PARKINSIN´s DISEASE(p.11) 1.2.1 Cognitive deficits (p.13) 1.2.2 Sleep parameters (p.18) 1.3 MULTISYSTEMATROPHIE (p.25) 1.3.1 Cognitive deficits (p.26) 1.3.2 Sleep parameters (p.30) 1.4 REM SLEEP BEHAVIOR DISORDER (p.33) 1.4.1 Cognitive deficits (p.36) 1.4.2 Sleep parameters (p.39) 2. Summary of sleep and cognition (p.42) 3. Summary of current studies (p.46) 4. Questions and hypothesis (p.52) III. METHODOLOGY (p.54) 1. Preface (p.54) 2. Indipendent variable (p.54) 2.1 Participants (p.54) 2.1.1 In/Out Criterias(p.54) 2.1.1.1 Parkinson´s disease (p.55) 2.1.1.2 Multisystematrophy (p.56) 2.1.1.3 REM Sleep behavior disorder (p.58) 2.2 Study design(p.58) 3. Dependent Variable (p.60) 3.1 Cognitive test (p.60) 3.1.1 CERAD (p.60) 3.1.2 More cognitive tests (p.63) 3.2 Polysomnography (p.69) 4. Statistic (p.70) IV. RESULTS (p.72) 1. Demographic and clinical data (p.72) 2. Results of the cognitive tests (p.74) 3. Results of the Polysomnography (p.80) 4. Correlation of sleepparameters and controls(p.84) 5. Correlation of cognitive variables and Polysomnography(p.85) 5.1 CERAD tests (p.85) 5.2 More cognitive tests (p.87) 5.3 TAP (p.89) 6. Summary (p.89) V. DISCUSSION (p.91) 1. Aim of this study (p.91) 2. Results (p.91) 3. Cognition (p.93) 4. Polysomnography (p.103) 5. Correlation Cognition and Polysomnography (p.114) 6. Limitations of this study (p.118) 7. Clinical relevance (p.122) VI. Summary (p.124) VII. Index of literature (p.127) VIII. Index of graphics and charts (p.142) IX. Appendix (p.144) 1. Charts (p.144) 2. List of abbreviations (p.145) 3. Explanations (p.147) 4. Teachers (p.148) 5. Acknowledgment (p.150) 6. Word of Honor (p.150)