Insights into Protein-Ligand Molecular Recognition: Thermodynamic, Kinetic and Structural Characterization of Inhibitor Binding to Aldose Reductase and Carbonic Anhydrase II

Two pathological relevant proteins, human aldose reductase and human carbonic anhydrase, were used as model proteins to get insights into the process of molecular recognition. The thermodynamics and kinetics of the formation process of protein ligand complex formation were studied.

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Rechlin, Chris
Awduron Eraill: Klebe, Gerhard (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2015
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Disgrifiad
Crynodeb:Two pathological relevant proteins, human aldose reductase and human carbonic anhydrase, were used as model proteins to get insights into the process of molecular recognition. The thermodynamics and kinetics of the formation process of protein ligand complex formation were studied.
Disgrifiad Corfforoll:245 Seiten
DOI:10.17192/z2015.0464