Inhibitors of p53 and HIF-prolyl-4-hydroxylases provide mitochondrial protection in a model of oxytosis

Inhibitors of p53 and HIF-prolyl-4-hydroxylases provide mitochondrial protection in a model of oxytosis

Mitochondrial dysfunction and demise are hallmarks of many neurological disorders and neurodegenerative diseases. Since mitochondria are the key organelles providing energy, they are regarded as the power house of the cell. Under conditions of stress, mitochondria regulate the ‘point of no return’...

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Autore principale: Neitemeier, Sandra
Altri autori: Culmsee, Carsten (Prof. Dr.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2015
Soggetti:
oxytosis
p53
Zelltod
Mitochondrium
neuronal cell death
Protein p53
Oxidativer Stress
HIF-prolyl-4-hydroxylase
Medizin
mitochondria
Medical sciences Medicine
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