PLZF/RARalpha binding partners and their influence on the induction of acute promyelocytic leukaemia

PLZF/RARalpha binding partners and their influence on the induction of acute promyelocytic leukaemia

The acute promyelocytic leukaemia (APL) accounts for 10% of the adult AML patients. APL patients carry chromosomal translocations involving the rarα gene on chromosome 17. The most frequent translocations lead to the expression of the fusion proteins PML/RARα (98%; t(15;17)) and PLZF/RARα (1%; t(11;...

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Detalles Bibliográficos
Autor Principal: Frech, Miriam
Outros autores: Renkawitz-Pohl, Renate (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato: Dissertation
Idioma:inglés
Publicado: Philipps-Universität Marburg 2014
Schlagworte:
Translokation
differentiation block
Naturwissenschaften
Chromosomenaberration
Leukämie
acute promyelocytic leukaemia
high molecular weight complex
Akute myeloische Leukämie
Natural sciences & mathematics
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