lin-Benzopurines as Inhibitors of tRNA-Guanine Transglycosylase: Perturbance of Homodimer Formation, Import of Water Clusters and Determinants of Crystallographical Disorder

lin-Benzopurines as Inhibitors of tRNA-Guanine Transglycosylase: Perturbance of Homodimer Formation, Import of Water Clusters and Determinants of Crystallographical Disorder

In this thesis different methods of structure-based drug design have been applied to develop TGT inhibitors suiting the manifold purposes of the tackled projects. TGT is not only a putative target for the treatment of Shigellosis, but additionally represents a well-accessible model system to study m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijä: Immekus, Florian Peter Philip
Muut tekijät: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Aineistotyyppi: Dissertation
Kieli:englanti
Julkaistu: Philipps-Universität Marburg 2012
Aiheet:
water cluster analysis
Inhibitordesign
Protein Protein Interaktion
Wassernetzwerkanalyse
Enzyminhibitor
Proteinkristallographie
protein protein interaction
Queuin-tRNS-Ribosyltransferase
inhibitor design
Naturwissenschaften
Natural sciences & mathematics
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Internet

PDF-kokoteksti

Saatavuus:
Hyllypaikka: urn:nbn:de:hebis:04-z2013-00742
Julkaisupäivä: 2013-02-11
Datum der Annahme: 2013-01-30
Downloads: 46 (2024), 127 (2023), 114 (2022), 89 (2021), 120 (2020), 85 (2019), 62 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Linkki aineistoon: https://archiv.ub.uni-marburg.de/diss/z2013/0074
https://doi.org/10.17192/z2013.0074

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