lin-Benzopurines as Inhibitors of tRNA-Guanine Transglycosylase: Perturbance of Homodimer Formation, Import of Water Clusters and Determinants of Crystallographical Disorder
In this thesis different methods of structure-based drug design have been applied to develop TGT inhibitors suiting the manifold purposes of the tackled projects. TGT is not only a putative target for the treatment of Shigellosis, but additionally represents a well-accessible model system to study m...
Wedi'i Gadw mewn:
Prif Awdur: | |
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Awduron Eraill: | |
Fformat: | Dissertation |
Iaith: | Saesneg |
Cyhoeddwyd: |
Philipps-Universität Marburg
2012
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Pynciau: | |
Mynediad Ar-lein: | Testun PDF llawn |
Tagiau: |
Ychwanegu Tag
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Rhyngrwyd
Testun PDF llawnRhif Galw: |
urn:nbn:de:hebis:04-z2013-00742 |
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Dyddiad Cyhoeddi: |
2013-02-11 |
Datum der Annahme: |
2013-01-30 |
Downloads: |
46 (2024), 127 (2023), 114 (2022), 89 (2021), 120 (2020), 85 (2019), 62 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL mynediad: |
https://archiv.ub.uni-marburg.de/diss/z2013/0074 https://doi.org/10.17192/z2013.0074 |