Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Aim: To evaluate if the lentiviral accessory protein Nef can down-regulate CXCR4 in tumor cells and affect tumor cell proliferation, migration and angiogenesis. Materials and Methods: HeLa-ACC cells were transfected with Nef from SIVmac239 and expression levels of cell surface CXCR4 were monitored b...

Full description

Saved in:
Bibliographic Details
Main Author: Cai, Chengzhong
Contributors: Mandic, Robert (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2012
Subjects:
Affenimmundefizienzvirus
HeLa
Chemokine
Chemokine CXCL12
Medizin
SDF-1
Tumor
HeLa-Zelle
Nef
SIV
CXCR4
Gen nef
Medical sciences Medicine
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!
No references were found for this record.

Similar Items