Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Aim: To evaluate if the lentiviral accessory protein Nef can down-regulate CXCR4 in tumor cells and affect tumor cell proliferation, migration and angiogenesis. Materials and Methods: HeLa-ACC cells were transfected with Nef from SIVmac239 and expression levels of cell surface CXCR4 were monitored b...

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Detalhes bibliográficos
Autor principal: Cai, Chengzhong
Outros Autores: Mandic, Robert (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2012
Assuntos:
Affenimmundefizienzvirus
HeLa
Chemokine
Chemokine CXCL12
Medizin
SDF-1
Tumor
HeLa-Zelle
Nef
SIV
CXCR4
Gen nef
Medical sciences Medicine
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Detalhes do Exemplar
Área/Cota: urn:nbn:de:hebis:04-z2011-08778
Publikationsdatum: 2012-02-09
Datum der Annahme: 2012-01-06
Downloads: 24 (2024), 71 (2023), 112 (2022), 85 (2021), 62 (2020), 92 (2019), 47 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2011/0877
https://doi.org/10.17192/z2011.0877

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