Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Aim: To evaluate if the lentiviral accessory protein Nef can down-regulate CXCR4 in tumor cells and affect tumor cell proliferation, migration and angiogenesis. Materials and Methods: HeLa-ACC cells were transfected with Nef from SIVmac239 and expression levels of cell surface CXCR4 were monitored b...

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Bibliografische gegevens
Hoofdauteur: Cai, Chengzhong
Andere auteurs: Mandic, Robert (Prof. Dr.) (Thesis begeleider)
Formaat: Dissertation
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2012
Onderwerpen:
Affenimmundefizienzvirus
HeLa
Chemokine
Chemokine CXCL12
Medizin
SDF-1
Tumor
HeLa-Zelle
Nef
SIV
CXCR4
Gen nef
Medical sciences Medicine
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Plaatsingsnummer: urn:nbn:de:hebis:04-z2011-08778
Publicatiedatum: 2012-02-09
Datum der Annahme: 2012-01-06
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL naar item: https://archiv.ub.uni-marburg.de/diss/z2011/0877
https://doi.org/10.17192/z2011.0877

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