Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis

Diese Studie untersuchte an 111 Patienten mit Sepsis den Zusammenhang der zeitlichen Kinetik von Interleukin 6, Procalcitonin und der HLA-DR-Expression auf Monozyten mit dem Krankheitsverlauf sowie ihre Eignung zu einer frühen Risikostratifizierung. Es zeigte sich in den aufgestellten logistischen R...

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Bibliographic Details
Main Author: Schumann, Florian
Contributors: Max, M. (PD Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2011
Online Access:PDF Full Text
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This study analysed at 111 patients with sepsis the relation of the temporal kinetics of interleukin 6, procalcitonin and HLA-DR expression on monocytes with the disease and their ability for early risk stratification. It was found in the developed logistic regression models a statistical trend, that after 48 hours the HLA-DR expression on monocytes can give evidence of the further clinical development of the patient and thus potentially of the effectiveness of the current therapy of sepsis (p = 0.0923). Certainly there are further multicenter studies with larger study populations necessary to detect a statistically significant and positive effect on the outcome. For PCT and IL-6 there was neither a statistical significance nor a statistical trend found in this regard. In addition, in the created Cox regression models the already by other research groups proven suitability of the APACHE II score for early risk stratification was confirmed (p = 0.0098). For IL-6 as well such an association with the risk of death could be shown (p = 0.0148). For PCT and HLA-DR no association with the risk of death was detectable.