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RNA recognition in immune cells
RNA stellt einen Stimulus für das angeborene Immunsystem durch die Aktivierung der endosomalen TLRs (3, 7 und 8) oder der zytosolischen RNA Sensoren (RIG-I und MDA-5) dar. Die Erkennung von RNA resultiert in der Sekretion von Typ-I Interferonen und / oder proinflammatorischen Zytokinen. Fremd-RNA wi...
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| Format: | Dissertation |
| Sprache: | Englisch |
| Veröffentlicht: |
Philipps-Universität Marburg
2010
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| Schlagworte: | |
| Online-Zugang: | PDF-Volltext |
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RNA provides a stimulus for innate immunity either by activating the endosomal TLRs (3, 7 and 8) or by triggering cytosolic RNA sensors (RIG-I and MDA-5). RNA recognition results in the secretion of type-I interferons and / or proinflammatory cytokines. Recognition of foreign RNA is thought to occur due to the presence of non-self strucures, such as abundance of nucleotide modifications, ds conformation or the presence of a terminal 5-triphosphate. Discrimination between self and non-self-RNAs is very important to prevent constant induction of type-I IFNs which would lead to autoimmune responses. However, the exact structural requirements for RNA recognition are still mainly unidentified. Within this work, the influence of RNA modifications and the immunostimulatory potentials of RNA from influenza-infected cells, small self-RNAs and cathelicidin/RNA complexes were analyzed.