Molecular characterization of TGF-β mediated cancer cell proliferation

TGF-β inhibits epithelial cell growth through Smad-dependent induction of a cell cycle arrest at G1. During tumor progression, however, many tumor cells escape from TGF-β growth suppression due to either functional or genetic disruption of the Smad signaling pathway. In late tumor stages, TGF-β s...

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Bibliografski detalji
Glavni autor: Singh, Garima
Daljnji autori: Ellenrieder, Volker (Prof. Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:engleski
Izdano: Philipps-Universität Marburg 2010
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