Toxicological Evaluation of Poly(ethylene imine) -based non-viral vector systems for pulmonary siRNA application

Toxicological Evaluation of Poly(ethylene imine) -based non-viral vector systems for pulmonary siRNA application

In this thesis, toxicity of PEI-based non-viral vector systems for siRNA application into the lungs was comprehensively described and analyzed in vitro as well as in vivo. Chapter 1 introduced in basic information about the lung anatomy and physiology and general considerations for pulmonary appli...

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Bibliografske podrobnosti
Glavni avtor: Beyerle, Andrea
Drugi avtorji: Kissel, Thomas (Prof.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2010
Teme:
Cytotoxicity
RNS-Interferenz
Toxikologische Bewertung
oxidative stress
Naturwissenschaften
Wasserlösliche Polymere
Polyethylenimin (PEI)
Oxidativer Stress
pulmonary application
Entzündung
In vivo
Poly(ethylene imine)
Lunge
Cytotoxizität
In vitro
siRNA
inflammation
Natural sciences & mathematics
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