Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens...

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Détails bibliographiques
Auteur principal: Hoffmann-Geim, Frank
Autres auteurs: Buckel, Wolfgang (Prof. Dr.) (Directeur de thèse)
Format: Dissertation
Langue:anglais
Publié: Philipps-Universität Marburg 2009
Sujets:
Simulation
Modellierung
Biowissenschaften, Biologie
Carbonyl-Reductase
Röntgenstruktur
Drug Design
Hydroxysteroid-Dehydrogenasen
SDR
Molekulardynamik
3alpha HSD/CR
Molecular dynamic
Hydroxysteroiddehydrogenase
Life sciences
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