TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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Bibliográfalaš dieđut
Váldodahkki: Ritschel, Tina
Eará dahkkit: Klebe, Gerhard (Prof., Dr.) (BetreuerIn (Doktorarbeit))
Materiálatiipa: Dissertation
Giella:eaŋgalasgiella
Almmustuhtton: Philipps-Universität Marburg 2009
Fáttát:
Enzyme kinetic
Englisch
pKa shifts
Computational chemistry
tRNA
tRANA
Enzyminhibitor
TGT
Enzymkinetik
X-ray crystallography
X-ray Kristallographie
Arzneimitteldesign
pKa-Shifts
English
Liŋkkat:PDF-ollesdeaksta
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