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TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation
In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...
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| Format: | Dissertation |
| Sprog: | engelsk |
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Philipps-Universität Marburg
2009
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| Online adgang: | PDF-Volltext |
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