TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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Bibliografski detalji
Glavni autor: Ritschel, Tina
Daljnji autori: Klebe, Gerhard (Prof., Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:engleski
Izdano: Philipps-Universität Marburg 2009
Teme:
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