TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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Détails bibliographiques
Auteur principal: Ritschel, Tina
Autres auteurs: Klebe, Gerhard (Prof., Dr.) (Directeur de thèse)
Format: Dissertation
Langue:anglais
Publié: Philipps-Universität Marburg 2009
Sujets:
Enzyme kinetic
Englisch
pKa shifts
Computational chemistry
tRNA
tRANA
Enzyminhibitor
TGT
Enzymkinetik
X-ray crystallography
X-ray Kristallographie
Arzneimitteldesign
pKa-Shifts
English
Accès en ligne:Texte intégral en PDF
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