TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

TGT a Drug Target to Study pKa Shifts, Residual Solvation & Protein-Protein Interface Formation

In this thesis multiple computer aided methods of structure based drug design along with X-ray crystallography and kinetic measurements were used to investigate inhibitors of tRNA-guanine transglycosylase (TGT) a putative target for a new specific antibiotic against Shigella bacteria. Within a year...

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I tiakina i:
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Kaituhi matua: Ritschel, Tina
Ētahi atu kaituhi: Klebe, Gerhard (Prof., Dr.) (BetreuerIn (Doktorarbeit))
Hōputu: Dissertation
Reo:Ingarihi
I whakaputaina: Philipps-Universität Marburg 2009
Ngā marau:
Enzyme kinetic
Englisch
pKa shifts
Computational chemistry
tRNA
tRANA
Enzyminhibitor
TGT
Enzymkinetik
X-ray crystallography
X-ray Kristallographie
Arzneimitteldesign
pKa-Shifts
English
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Ngā taipitopito puringa mai i
Tau karanga: urn:nbn:de:hebis:04-z2009-04739
Rā whakaputa: 2009-10-09
Datum der Annahme: 2009-08-20
Downloads: 36 (2024), 99 (2023), 98 (2022), 97 (2021), 101 (2020), 97 (2019), 56 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2009/0473
https://doi.org/10.17192/z2009.0473

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