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Zusammenhang zwischen schlafbezogenen Atmungsstörungen (OSA) und nächtlichen myokardialen Ischämien bei Patienten mit KHK
Patienten mit obstruktiver Schlafapnoe (OSA) haben ein erhöhtes Risiko für Mortalität und Morbidität, welches auf Begleiterkrankungen des Herz-Kreislauf-Systems zurückgeführt werden kann. OSA tritt mit einer Häufigkeit von 30-40 % bei Patienten mit Koronarer Herzkrankheit (KHK) auf. Ziel dieser Arbe...
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| Format: | Dissertation |
| Sprache: | Deutsch |
| Veröffentlicht: |
Philipps-Universität Marburg
2008
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| Online Zugang: | PDF-Volltext |
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Background: Patients suffering from sleep disordered breathing have a high rate of morbidity and mortality caused by accompanying cardio-vascular diseases. Sleep disordered breathing is diagnosed in 30 to 40% of patients with coronary heart disease. The aim of this study was to examine the relationship of nocturnal myocardial ischemia and disordered breathing in patients with coronary heart disease. Methods: We used for this observational study a 12-lead long term Holter recording(WelchAllyn CardioPerfect Holter-ECG) and a synchronized sleep apnea screening device (SOMNOcheck WM 94100, Weinmann) to examine nocturnal breathing disorders and depressions in the ST-segment. Results: 19 patients with coronary heart disease were included. An apnea-hypopneaindex(AHI) of more than 20 was observed in 7 patients (36,8%) (range 21 to 58), an AHI of 10 to 20 was observed in 3 subjects (range 11 to 19). 13 episodes of nocturnal depressions in the ST-segment were found in 8 subjects. 11 depressions occurred after a preceding desaturation, 2 without. Conclusion: The supposed relation between nocturnal desaturation and myocardial ischemia could not be verified. Other factors such as a change in the sympathovagal balance could contribute to nocturnal myocardial ischemia.