Structural and thermodynamic characterization of inhibitor binding to aldose reductase: Insights into binding modes, driving forces and selectivity determinants

Structural and thermodynamic characterization of inhibitor binding to aldose reductase: Insights into binding modes, driving forces and selectivity determinants

The TIM-barrel folded enzyme Aldose reductase (ALR2) is a valuable model system to study structural and thermodynamic features of inhibitor binding and, furthermore, represents an excellent drug target. To prevent diabetic complications derived from enhanced glucose flux via the polyol pathway the d...

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Detalles Bibliográficos
Autor Principal: Steuber, Holger
Outros autores: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato: Dissertation
Idioma:inglés
Publicado: Philipps-Universität Marburg 2007
Schlagworte:
Aldose reductase
Crystal structure
Selectivity
Chemie
Wirkstoffdesign
Protein-Ligand-Wechselwirkung
Drug design
Selektivität
Kristallstruktur
Protein ligand interaction
Aldose Reduktase
Chemistry & allied sciences
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