Structural and thermodynamic characterization of inhibitor binding to aldose reductase: Insights into binding modes, driving forces and selectivity determinants

Steuber, Holger

Structural and thermodynamic characterization of inhibitor binding to aldose reductase: Insights into binding modes, driving forces and selectivity determinants

The TIM-barrel folded enzyme Aldose reductase (ALR2) is a valuable model system to study structural and thermodynamic features of inhibitor binding and, furthermore, represents an excellent drug target. To prevent diabetic complications derived from enhanced glucose flux via the polyol pathway the d...

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Κύριος συγγραφέας:	Steuber, Holger
Άλλοι συγγραφείς:	Klebe, Gerhard (Prof. Dr.) (Εισηγητής διατριβής)
Μορφή:	Dissertation
Γλώσσα:	Αγγλικά
Έκδοση:	Philipps-Universität Marburg 2007
Θέματα:	Aldose reductase Crystal structure Selectivity Chemie Wirkstoffdesign Protein-Ligand-Wechselwirkung Drug design Selektivität Kristallstruktur Protein ligand interaction Aldose Reduktase Chemistry & allied sciences
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Structural and thermodynamic characterization of inhibitor binding to aldose reductase: Insights into binding modes, driving forces and selectivity determinants

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