Cyclooxygenaseisoformaktivität im ZNS von Mäusen

The non-steroidal antiinflammatory drug dipyrone is a popular, potent non-opioid analgesic and antipyretic with analgesic potency comparable to that of opioids. Apart from its spasmolytic effect, the weak antiinflammatory effects and the absence of an gastro-renal side effects are features that distinguish it from the common non-steroidal antiinflammatory drugs. The molecular mechanism of action of dipyrone is yet not known. My data support the idea,that the pharmacological effects of the prodrug dipyrone are at least partly due to a arachidonoyl amide of methyl-amino-antipyrine, which is a part of the dipyrone-metabolic pathway. This drug is formed by fetty acid amide hydrolase in the CNS and ist a potent cyclooxygenase inhibitor and cannabinoid receptor ligand.