The surfactin biosynthetic complex of Bacillus subtilis: COM domain-mediated biocombinatorial synthesis, and single step purification of native multi-modular NRPSs and multi-enzyme complexes

Most biosynthetic templates for the assembly of peptide natural products are composed of two or more nonribosomal peptide synthetases (NRPSs). For example, the surfactin biosynthetic complex consists of three NRPSs (SrfA-A, SrfA-B, and SrfA-C), which are encoded by the polycistronic srfA operon with...

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Autor principal: Chiocchini, Claudia
Altres autors: Buckel, Wolfgang (Prof.) (Assessor de tesis)
Format: Dissertation
Idioma:anglès
Publicat: Philipps-Universität Marburg 2006
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