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Korrelation der Pharmakokinetik von Etoposid aus Etoposidphosphat mit klinischen Parametern
Die Pharmakokinetik von Etoposid nach Applikation von Etoposidphosphat wurde an einer Gruppe von 30 Patienten untersucht. Die Werte wurden mit Alter, Nierenfunktions- und Leberparametern sowie mit der Höhe der alkalischen Phosphatase korreliert. Es zeigte sich eine signifikante Reduktion der Elimina...
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| Định dạng: | Dissertation |
| Ngôn ngữ: | Tiếng Đức |
| Được phát hành: |
Philipps-Universität Marburg
2006
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| Những chủ đề: | |
| Truy cập trực tuyến: | Bài toàn văn PDF |
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Pharmacokinetics of etoposide after application of etoposide phosphate was investigated in a group of 30 patients. The results were correlated with age, AP, renal and liver parameters. In patients with renal insufficiency the elimination of etoposide from etposide phosphate was significantly reduced. Higher AP-levels were combined with higher peak-levels of etoposide. Age and abnormal hepatic parameters had no influence on etoposide pharmacokinetics.