Insulin nanocomplexes formed by self-assembly from amine-modified poly(vinyl alcohol)-graft-poly(L-Lactide) for non-invasive mucosal delivery: Preparation, characterization and in vivo investigations

Insulin nanocomplexes formed by self-assembly from amine-modified poly(vinyl alcohol)-graft-poly(L-Lactide) for non-invasive mucosal delivery: Preparation, characterization and in vivo investigations

In this work biodegradable DEAPA-PVAL-g-PLLA nanocomplexes were investigated as a colloidal peptide carrier system for non-invasive transmucosal insulin delivery. Chapter 1 describes the basic fundamentals of insulin therapy, current status, problems and future trends. The pathogenesis of diabetes m...

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Detalhes bibliográficos
Autor principal: Simon, Michael
Outros Autores: Kissel, Thomas (Prof. Dr.) (Orientador)
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2005
Assuntos:
Nanopartikel
Drug Delivery System
Nasale Applikation
Modifizierte Polymere
Nichtinvasive Insulinapplikation
Therapeutisches System
Insulin
Non-invasive Application
Diabetes mellitus
Nanoparticles
Modified Polymers
Medizin
Medical sciences Medicine
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