Charakterisierung von Osteoprotegerin (OPG) und Receptor Activator of NF-kB-Ligand (RANKL) in der Schilddrüse

Die Aufgabe der für die Immunantwort und den Knochenstoffwechsel entscheidenden TNF-Liganden und -Rezeptoren-Familienmitglieder RANKL, OPG und RANK war in der Pathophysiologie und Physiologie der Schilddrüse lange ungeklärt. Die Ergebnisse dieser Arbeit zeigen, dass die Schilddrüse sowohl ein Ort de...

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Bibliographic Details
Main Author: Kluger, Sibylle
Contributors: Hofbauer, L. C. (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2005
Online Access:PDF Full Text
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Receptor activator of NF-kB-Ligand (RANKL) and osteoprotegerin (OPG) play essential roles in bone metabolism and immun responses. RANKL activates RANK, wich is expressed by osteoclasts and dendritic cells, whereas OPG acts as its decoy receptor. The role of RANKL and OPG in thyroid physiologie remainded unclear. The shown data suggest that RANKL and OPG are produced in the thyroid galnd by thyroid follicular cells, are regulated by cytokines and TSHm, and are capable of modulating dendritic cell functions. Thus, these cytokines may represent important local immunmregulatory factors involved in the pathogenesis of autoimmun thyroid diseases.