Wirkung von Aminfluorid/Zinnfluorid, Triclosan und Acetylsalicylsäure auf die gingivale Entzündung

This placebo-controlled double-blind study was aimed at determining the effects of mouthrinses containing amine fluoride/stannous fluoride (AmF2/SnF2), triclosan and acetylsalicylic acid (ASA) on the subgingival microbiotic flora during experimental gingivitis and subsequent rinsing phase. 44 subjects participated in the study. To establish healthy gingival conditions, all subjects underwent a 3-week period of professional tooth cleaning and oral hygiene instruction. Plaque and gingivitis assessments, gingival crevicular fluid assessment and microbial sampling were performed at baseline. At the second examination healthy conditions were recorded. For the next 14 days, the subjects were asked to abstain from any form of oral hygiene (experimental gingivitis phase). The 3rd and 4th examinations were performed 7 and 14 days after the second examination and was followed by random assignment of mouthrinses containing either AmF2/SnF2, triclosan, ASA or placebo. These mouthrinses were used for 22 days with no additional oral hygiene measures (rinsing phase). During this period the 5th and 6th examinations were performed at 25 and 36 days after the second examination. Microbiological evaluation of the subgingival plaque sampling was done by dark-field microscopy. Statistical analysis was based on the Kruskal-Wallis test and the Wilcoxon-Mann-Whitney test. The results of the dark-field microscopy showed that, in all treatment modalities, there was a reduction in the total number of cocci from the 2nd to the 6th examination, while motile rods showed an increase and non-motile rods remained constant throuout. The spirochetes, filaments and fusiform counts showed an increase during the experimental gingivitis phase as well as during the rinsing phase. However, no statistically significant inter-group differences were observed in influencing the subgingival microbiotic flora between the rinsing solutions after a 22 days rinsing period.