Mitogenic signaling by Gq/11-coupled receptors
By binding to their cognate GPCRs, many potent mitogens such as neuropeptides, angiotensin II or lysophosphatidic acid stimulate cell proliferation via engaging the ERK/MAPK cascade. As mentioned before, agonists stimulating Gq/11-coupled receptors activate PLCb isoforms thereby...
সংরক্ষণ করুন:
প্রধান লেখক: | |
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অন্যান্য লেখক: | |
বিন্যাস: | Dissertation |
ভাষা: | ইংরেজি |
প্রকাশিত: |
Philipps-Universität Marburg
2004
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বিষয়গুলি: | |
অনলাইন ব্যবহার করুন: | পিডিএফ এ সম্পূর্ন পাঠ |
ট্যাগগুলো: |
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সংক্ষিপ্ত: | By binding to their cognate GPCRs, many potent
mitogens such as neuropeptides, angiotensin II or
lysophosphatidic acid stimulate cell proliferation via engaging
the ERK/MAPK cascade. As mentioned before, agonists stimulating
Gq/11-coupled receptors activate PLCb isoforms thereby
activating PKCs and elevating [Ca2+]i. These two second
messengers represent key molecules for coupling Gq/11 proteins
to the ERK/MAPK cascade. In this work, by means of GnRH in
gonadotropic aT3-1 cells and galanin or bradykinin in SCLC
cells, different aspects of Gq/11-dependent mitogenic signaling
pathways were revealed. Our findings together with previous
reports underline the notion that signaling pathways emanating
from Gq/11-coupled receptors are tightly regulated in a cell-
and receptor-specific manner. |
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ডিওআই: | 10.17192/z2004.0120 |