Drug Delivery of Oligonucleotides at the Blood-Brain Barrier: a Therapeutic Strategy for Inflammatory Diseases of the Central Nervous System
In this project a vector for drug delivery into brain endothelial cells, consisting of an anti-transferrin receptor antibody and a complex of polyethylenimine (PEI) and an oligodeoxynucleotide (ODN) drug was evaluated. NF-kB decoys are short double-stranded ODNs, which contain a recognition sequence...
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