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Die Peptide CGRP, Adrenomedullin und PTHrP bewirken eine Dilatation der Koronargefäße durch Aktivierung von KATP-Kanälen.
CGRP, Adrenomedullin und PTHrP sind seit Mitte der 80er Jahre als vasoaktive Peptide bekannt. Bisher wurden Untersuchungen über die gefäßerweiternde Wirkung dieser Substanzen nur an Zellen oder nicht-isolierten Organen durchgeführt. Das isoliert perfundierte Mäuseherz zeichnet sich durch die isolier...
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| Formato: | Dissertation |
| Idioma: | alemão |
| Publicado em: |
Philipps-Universität Marburg
2002
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| Assuntos: | |
| Acesso em linha: | Texto Completo em Formato PDF |
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CGRP, adrenomedulline and PTHrP have been known for being vasoactive substances since the middle 80s. Up to now, research about their vasoactive potencial was only performed in cells and non-isolated organs. The isolated perfused mouse heart can show us an isolated view of the whole organ. Besides that, we know that there is a great homology of the mice genome to the human genome. We could show for the first time in the isolated perfused mouse heart that CGRP is a strong vasodilatating peptide adrenomedulline is a strong vasodilatating peptide PTHrP is a strong vasodilatating peptide CGRP and Adrenomedullin show almost identically effects used in the same concentration the KATP-channels play an extremely important role in vasodilatating effects of the peptides CGRP, adrenomedulline and PTHrP