Starre biomimetische Adrenalinrezeptor-Modelle
Im Rahmen dieser Arbeit wurden starre biomimetische Rezeptoren auf Bisphosphonat-Basis für Catecholamine, die eine wichtige Klasse von Hormonen und Neurotransmittern darstellen, entwickelt und synthetisiert. Diese makrozyklischen oder pinzettenförmigen Wirtverbindungen wurden durch 1H-NMR-Titratione...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2003
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| Online Access: | PDF Full Text |
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In this thesis rigid biomimetic receptors based on bisphosphonates were designed and synthesized for the recognition of catecholamines, an important class of hormones and neurotransmitters. The binding properties of these macrocyclic or tweezwers-shaped host molecules in polar solution were examined by 1H NMR titrations. Furthermore, the amphiphilic receptors were embedded in lipid monolayers at the air/water interface and showed strong and selective binding of adrenaline derivatives in this simple membrane model.