Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation

The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the biological significance of this difference is not clear. Here, we used molecular dynamics simulation to model the effects...

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Bibliografische gegevens

Hoofdauteurs:	Elli, Stefano, Raffaini, Giuseppina, Guerrini, Marco, Kosakovsky Pond, Sergei, Matrosovich, Mikhail
Formaat:	Artikel
Taal:	Engels
Gepubliceerd in:	Philipps-Universität Marburg 2023
Onderwerpen:	H5N1 neuraminidase substrate specificity natural selection Medizin MD simulation influenza Medical sciences Medicine
Online toegang:	PDF Full text
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