KLF4‑mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

KLF4‑mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands (NKG2D-L), including MICA. The absence of NK...

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Autoren: Alkhayer, Reem, Ponath, Vivane, Frech, Miriam, Adhikary, Till, Graumann, Johannes, Neubauer, Andreas, Pogge von Strandmann, Elke
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2023
Schlagworte:
Immune evasion
Natural killer cells
APTO253
Medizin
Immunotherapy
NKG2D/NKG2D-ligand axis
Medical sciences Medicine
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Signatur: urn:nbn:de:hebis:04-es2024-07910
Publikationsdatum: 2024-01-23
Quelle: Erstveröffentlichung: Alkhayer, R., Ponath, V., Frech, M. et al. KLF4-mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP. Cell Commun Signal 21, 94 (2023). https://doi.org/10.1186/s12964-023-01118-z
Downloads: 21 (2024)
Lizenz: https://creativecommons.org/licenses/by/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2024/0791
https://doi.org/10.1186/s12964-023-01118-z

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